Micro-injection moulding (microIM) was used for the production of enteric tablets of plasticised\nand unplasticised solid dispersions of poly(vinylpyrrolidone-vinyl acetate) (PVPVA), and the eect\nof the mechanical and thermal treatment on the properties of the dispersions was investigated.\nThe physical state of the systems showed to be unaltered by the microIM step, maintaining the drug in\nthe amorphous state. The dissolution profile of the tablets showed a slower dissolution rate due to\nthe lower surface to volume ratio compared to the extruded strands. The lack of solubility of the\ndoses in the acidic medium as a consequence of the acidity of indomethacin (IND) was observed.\nHowever, in neutral pH the drug dissolution showed slower rates without affecting the dissolution\nextent, showing a potential application for the development of controlled release doses. Overall,\nthe production of tablets of amorphous solid dispersions (ASD), coupling hot-melt extrusion (HME)\nand microIM, proved to be a successful approach towards a continuous automated manufacturing process\nto improve the aqueous solubility of poorly water-soluble drugs.
Loading....